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Tobacco use most often begins in adolescence, a time when exposure to nicotine, the addictive substance in tobacco, can be especially harmful to teens developing brain ( SN: 6/30/15 )

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The authors also note an important limitation of the study: data collection is not equally reliable all over the world, so in some areas, the damage (especially that caused by illegal drugs) might not be properly understood this is especially the case in Africa, Caribbean, and some regions of Latin America and Asia

Yes, nicotine can worsen anxiety or panic in some individuals, especially those with sympathetic dominance, dysautonomia, trauma-related nervous system patterns, histamine intolerance, or stimulant sensitivity